Frank Osterroth;Christoph Bruecher;Niklas Czeloth;Christoph Uherek;Peter Röttgen;Chantal Zuber;Benjamin Daelken;André Engling
发明人:
Frank Osterroth,Christoph Uherek,Christoph Bruecher,Peter Röttgen,Benjamin Daelken,André Engling,Chantal Zuber,Niklas Czeloth
申请号：
US13512712
公开号：
US08956607B2
申请日:
2010.11.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α(IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor； and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
