Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE)

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专利权人:

Biotest AG

发明人:

Osterroth, Frank,Uherek, Christoph,Bruecher, Christoph,Rottgen, Peter,Daelken, Benjamin,Engling, Andre,Zuber, Chantal,Czeloth, Niklas

申请号：

AU2010323037

公开号：

AU2010323037B2

申请日:

2010.11.30

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor； and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.

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