Niaz Banaei,Jeffrey S. Glenn,Rajiv Lochan Gaur,Tran Van,Gary K. Schoolnik,Edward Pham
申请号：
US14918404
公开号：
US20160113919A1
申请日:
2015.10.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This disclosure provides a method of treating a subject infected with a mycobacteria of the M. tuberculosis complex or infected with an atypical mycobacterium. Aspects of the method include administering to a subject in need thereof a therapeutically effective amount of an enantiomerically pure (R)-chloroquine agent. The (R)-chloroquine agent may be an analog or derivate of chloroquine having a particular stereochemistry at the position located alpha to the amino-quinoline core of the chloroquine agent. Also provided are methods of inhibiting mycobacteria of the M. tuberculosis complex or other atypical mycobacteria in a cell. Kits and pharmaceutical compositions for practicing the subject methods are also provided.
