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ANTIBAKTERIJSKI DERIVATI KINOLINA
专利权人:
JANSSEN PHARMACEUTICA NV
发明人:
GUILLEMONT, J.E.G.,LANÇOIS, D.F.A.,PASQUIER, E.T.J.,ANDRIES, K.J.L.M.,KOUL, ANIL
申请号:
HRP20151308
公开号:
HRP20151308T1
申请日:
2015.12.01
申请国别(地区):
HR
年份:
2016
代理人:
摘要:
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds.
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