Described herein are novel methods and kits for treating mycobacterium infections with KGF. The methods include administering an amount of KGF effective to treat the mycobacterium infection. The mycobacterium may be M. tuberculosis, drug resistant strains of M. tuberculosis, or atypical mycobacterium. The infections may be pulmonary infections. The method and kit may further include additional antimicrobial compounds effective against mycobacterium infections.