GUILLEMONT J.E.G. JOHNSON & JOHNSON PHARM. R&D,LANCOIS D.F.A. JOHNSON & JOHNSSON PHARM. R&D,PASQUIER E.T.J. JOHNSON & JOHNSSON PHARM. R&D,ANDRIES K.J.L.M. C/O JANSSEN PHARMACEUTICA N.V.,KOUL ANIL C/O,GUILLEMONT J.E.G. Johnson & Johnson Pharm. R&D,LANCOIS D.F.A. Johnson & Johnsson Pharm. R&D,PASQUIER E.T.J.
申请号：
SI200631998
公开号：
SI1912948T1
申请日:
2006.07.26
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds.
