OXOBY, Mayalen,ATAMANYUK, Dmytro,DENIS, Alexis,GERUSZ, Vincent,LEDOUSSAL, Benoît,BONVIN, Yannick,DESROY, Nicolas,GOLD, Johan,MOREAU, François
申请号：
EPEP2012/061428
公开号：
WO2012/172043A1
申请日:
2012.06.15
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The invention relates to the compounds of general formula (I) and their addition salts thereof with acids and bases: wherein A is phenyl, naphthyl and 5-10 membered monocyclic or bicyclic unsaturated heterocycle, optionally substituted by a group R1 which is as defined in the application and is itself optionally substitutes by a group R2 which is as defined in the application and is itself optionally substituted by a group R3 which is defined in the application, Y and W, identical or different, are H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, phenyl or 4-10 monocyclic or bicyclic saturated or unsaturated heterocycle, optionally substituted by R1, or Y and/or W form a 4-10 membered cycle with R1, or Y and W form with N a saturated or unsaturated nitrogenous 4-10 membered mono, bi or tricyclic system, fused, bridged or spiro system, said system being optionally substituted by R1, said system being different from morpholine, with the proviso that when Y and A are phenyl or heterocycle, W is not H, a process and intermediates for their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them.Cette invention concerne des composés de formule générale (I) et leurs sels daddition avec des acides et des bases, ainsi quun procédé et des intermédiaires pour les préparer et les utiliser en prévention et thérapie antibactérienne, seuls ou en association avec des antibactériens, des agents antivirulence ou des médicaments renforçant les défenses immunitaires innées de lhôte, et des compositions pharmaceutiques et associations les contenant. Dans la formule (I), A est phényle, naphtyle et hétérocycle monocyclique ou bicyclique insaturé ayant de 5 à 10 chaînons, éventuellement substitué par un groupe R1 qui est tel que défini dans la demande, lui-même éventuellement substitué par u
