CHANDRASEKAR VENKATARAMANI,MICHAEL GRAUPE,BRITTON KENNETH CORKEY,ELFATIH ELZEIN,ROBERT H. JIANG,RAO V. KALLA,DMITRY KOLTUN,XIAOFEN LI,RUBEN MARTINEZ,ERIC Q. PARKHILL,THAO PERRY,JEFF ZABLOCKI,JUAN GUER
申请号:
PT12735400
公开号:
PT2726469E
申请日:
2012.06.29
申请国别(地区):
PT
年份:
2015
代理人:
摘要:
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.