Plasminogen replacement therapy for plasminogen-deficiency

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专利权人:

Prometic Biotherapeutics; Inc.

发明人:

Robitaille, Martin,Thibaudeau, Karen,Laurin, Pierre,Plum, Stacy

申请号：

AU2016347863

公开号：

AU2016347863A1

申请日:

2016.11.03

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Subjects of the invention are a method of plasminogen supplementation in a plasminogen-deficient subject, and method for the treatment of plasminogen-deficiency in a plasminogen-deficient subject. These methods comprise administering to the plasminogen-deficient subject a dose of plasminogen, and more particularly Glu-plasminogen, for increasing the subject plasminogen activity level by at least about 1 %, and more particularly by at least about 10%, of the normal plasminogen activity and for maintaining said increased plasminogen activity level over a supplementation period or a treatment period. The plasminogen-deficient subject of the present invention may suffer from Type-I, Type-ll plasminogen-deficiency or an acquired deficiency.

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