The present invention relates to method (MC4R) activity for enhancing normal melanocortin-4 receptor, in order to enhance the MC4R that has an impact of a MC4R protein foldings and/or processing with such a mutation. The present invention provides the method for the treatment of individual, has condition, and one of active cells of MC4R can be beneficial, such as obesity, passes through a effective amount of MC4R. of applicationThe pharmacological chaperone present invention provides the enhancing active MC4R of MC4R pharmacological chaperones. Invention further provides screening techniques to identify the MC4R for enhancing the pharmacological chaperones folded at endoplasmic reticulum (ER), in order to enhance the activity of MC4R in cell surface.
