Linda Gillian Durrant,Victoria Anne Brentville,Rachael Louise Metheringham
申请号：
US16007944
公开号：
US20180346537A1
申请日:
2018.06.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Anti-tumour immune responses to modified self-epitopes. The present invention relates to the use of tumour-associated epitopes in medicine and in particular in the treatment of cancer. The epitopes stimulate an immune reaction against the tumour and have a modification selected from deimination of arginine to citrulline, nitration of tyrosine, oxidation of tryptophan and deamination of glutamine or asparagine. The invention also relates to nucleic acids comprising sequences that encode such epitopes for use in the treatment of cancer.
