In one or more embodiments of the present invention, it provides a method, this method includes the steps that giving to cancer patient following: (a) the long-acting IL-2R beta selective agonists of IL-2R β volume of activation And (b) long-acting parts IL-15 of IL-15R volume of activation. In one or more embodiments of the present invention, a kind of composition is provided, the composition includes: the long-acting IL-2R beta selective agonists of IL-2R β volume of activation And the long-acting parts IL-15 of IL-15R volume of activation. In one or more embodiments of the present invention, a kind of kit is provided, which includes: the long-acting IL-2R beta selective agonists of IL-2R β volume of activation The long-acting parts IL-15 of IL-15R volume of activation And the operation instructions of the IL-2R beta selective agonists and the long-acting parts IL-15.
