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DERIVES D'ETHYNYLE A TITRE DE MODULATEURS DU RECEPTEUR METABOTROPIQUE DU GLUTAMATE
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
BIEMANS, BARBARA,GUBA, WOLFGANG,JAESCHKE, GEORG,LINDEMANN, LOTHAR,O,HARA, FIONN,RICCI, ANTONIO,RUEHER, DANIEL,VIEIRA, ERIC
申请号:
CA2984711
公开号:
CA2984711A1
申请日:
2016.07.11
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present invention relates to compounds of formula I wherein R1 is lower alkyl; R2 is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be in different positions; n is 0, 1 or 2; V/U are independently from each other O or CH2, wherein V and U cannot be simultaneously O; L is a five or six membered heteroaryl group, selected from or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2.
来源网站:
中国工程科技知识中心
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