JAESCHKE, GEORG,O,HARA, FIONN,PLANCHER, JEAN-MARC,RICCI, ANTONIO,RUEHER, DANIEL,VIEIRA, ERIC
申请号：
CA2983908
公开号：
CA2983908A1
申请日:
2016.08.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to compounds of formula (I) wherein R1 is hydrogen, F or CI； L is a bond or lower alkylene； R2 is -(CH2)nO-lower alkyl, lower alkyl substituted by halogen, -(CH2)nC(0)0-lower alkyl, phenyl substituted by lower alkyl or halogen, or is a 5 or 6-membered heteroaryl group, selected from pyridinyl, pyrimidinyl, pyridazinyl, thiazolyl, imidazolyl, pyrazolyl or triazolyl, which are optionally substituted by lower alkyl, halogen, lower alkoxy, =0, benzyloxy, cycloalkyloxy, hydroxy, cyano, lower alkyl substituted by halogen, or by -(CH2)nO-lower alkyl； n is 1, 2 or 3； R3 is hydrogen, lower alkyl or -(CH2)nO-lower alkyl； R4 is phenyl, pyridinyl or pyrimidinyl, optionally substituted by F； Y is CF or CCl； or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomers thereof. The compounds may be used for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2.
