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STABILISED VACCINE COMPOSITION
专利权人:
GlaxoSmithKline Biologicals; s.a.
发明人:
Dominique Ingrid LEMOINE,Sophie Valerie Anne Ponsard
申请号:
US14086038
公开号:
US20140193481A1
申请日:
2013.11.21
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A component for a HIV vaccine comprising:a) an immunogenic fusion protein comprising Nef or an immunogenic fragment or derivative thereof, and p17 Gag and/or p24 Gag or immunogenic fragments or derivatives thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them, andb) a stabilising agent selected from the group comprising or consisting of monothioglycerol, cysteine, N-acetyl cysteine or mixtures thereof.The invention also extends to HIV vaccines comprising the same and use in treatment/prevention of HIV.
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