1. An isolated polypeptide comprising a polypeptide is gp120 or gp140 HIV soluble polypeptide, stable in the conformation in which simultaneously exhibited both CD4-associated epitope, or epitope binding site CD4.2. An isolated polypeptide according to Claim. 1, where gp120 polypeptide or soluble polypeptide gp140 of HIV includes an inner domain comprising the layers 1, 2 and 3 and is stabilized with one or more interlayer contacts between said layers 1 and 2 and / or between said layers 2 and 3 formed disulfide svyazyu.3. . An isolated polypeptide according to claim 2, wherein a disulfide bond is formed between the cysteine residues at positions which are equivalent to one or more pairs of amino acids: V59C and S109C, V95C and W465C, V95C and R462C, V95C and L469C and / or N99S and R462C in SEQ ID NO : 2.4. An isolated polypeptide according to claim 1, characterized in that the stabilized polypeptide gp120 or soluble polypeptide gp140 of HIV comprising an amino acid sequence which has at least 90% identity with the internal domain sequence shown in SEQ ID NO:. 2 and comprises one or more pairs non-natural cysteine residues at positions which are equivalent to V59 and S109, V95 and W465, V95 and R462, V95 and L469 and / or H99 and R462 in SEQ ID NO: 2.5. An isolated polypeptide according to claim 1, characterized in that the stabilized polypeptide gp120 or soluble polypeptide gp140 of HIV comprising an amino acid sequence which has at least 90% identity with the sequence shown in SEQ ID NO:. 2 and comprises one or more pairs of non-natural residues cysteine at positions equivalent V59 and S109, V95 and W465, V95 and R462, V95 and L469 and / or H99 and R462 in SEQ ID NO: 2.6. An isolated polypeptide according to claim 1, characterized in that the stabilized polypeptide gp120 or gp140 HIV soluble polypeptide comprises one or more non-naturally encoded pairs of cysteine residues at positions corresponding to E268 and W90, 1103 and Q413 in SEQ ID NO:. 2.7.1. Выд
