SUNG YOUB JUNG,SUNG HWAN HONG,SE CHANG KWON,BYUNG SUN LEE,DAE JIN KIM,YONG HO HUH
申请号：
ARP120103742
公开号：
AR088267A1
申请日:
2012.10.05
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
A Derivative of the Blood coagulation factor VIIA Derivative of the Blood coagulation factor VIIa (facvii； each of the Union and facvlia is prepared by a Polymer that can Prolong the half-life in the blood of the derivative； each Complex FAC VII and VIIa is prepared by a Union of the conjugated C Vehicle； genes Odifican derivatives and facvii FAC Vila； expression vector comprising the Gene transformants I；Ntroducidos with expression vector； a method for preparing the derivatives facvii and facvlia transformants using: a method to prepare the complex conjugate and the facviia； a complex facviia prepared with the method； a Pharmaceutical composition for the Prevention or Treatment To Hemophilia comprising the derivativeConjugated or complex as active ingredient； and a Pharmaceutical composition for Blood clotting comprising the derivative as Active Ingredient, or complex conjugate. In addition, relates to a method for preventing or treating Hemophilia or to promote Blood clotting, which comprises administering to a subject a therapeutically effective amount of the composition.The facvii or facviia derivative can be conjugated to a vehicle which can improve the half-life in Blood while maintaining the activity of facvie or facvlia, and can be widely used in the development of effective Therapeutic or prophylactic Agents for Hemophilia.Un derivado del factor de coagulación sanguínea VII, un derivado del factor de coagulación sanguínea VIIa； cada uno de los conjugados FacVII y FacVlIa se prepara por unión a un polímero que puede prolongar la vida media en sangre del derivado； cada uno de los complejos Fac VII y VIIa se prepara por unión de un vehículo al conjugado； genes que codifican los derivados FacVII y Fac Vila； vectores de expresión que comprenden los genes； transformantes introducidos con los vectores de expresión； un método para preparar los derivados FacVII y FacVlIa usando los transformantes: un método para preparar el conjugado y el complejo FacVIIa； un comple
