KIM, DAE JIN,LEE, BYUNG SUN,HONG, SUNG HWAN,HUH, YONG HO,JUNG, SUNG YOUB,KWON, SE CHANG
申请号：
CA2851223
公开号：
CA2851223A1
申请日:
2012.10.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to a blood coagulation factor ? derivative, a blood coagulation factor ?a derivative, Fac? and Fac?a conjugates each prepared by linking a polymer capable of extending the blood half-life to the derivative, Fac? and ?a complexes each prepared by linking a carrier to the conjugate, genes encoding the Fac? and Fac?a derivatives, expression vectors comprising the genes, transformants introduced with the expression vectors, a method for preparing the Fac? and Fac?a derivatives using the transformants, a method for preparing the Fac?a conjugate and complex, a Fac?a complex prepared by the method, a pharmaceutical composition for the prevention or treatment of hemophilia comprising the derivative, conjugate, or complex as an active ingredient, and a pharmaceutical composition for blood coagulation comprising the derivative, conjugate, or complex as an active ingredient. Further, the present invention relates to a method for preventing or treating hemophilia or for promoting blood coagulation, comprising administering to a subject a therapeutically effective amount of the composition. The Fac? or Fac?a derivative of the present invention is able to bind with a carrier capable of improving the blood half-life while maintaining the activity of Fac? or Fac?a, and they can be widely used in the development of effective prophylactic or therapeutic agent for hemophilia.
