KIM, Dae Jin,KWON, Se Chang,JUNG, Sung Youb,LEE, Byung Sun,HONG, Sung Hwan,HUH, Yong Ho
申请号：
MX2014004099
公开号：
MX354493B
申请日:
2012.10.05
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
The present invention relates to a blood coagulation factor VII derivative, a blood coagulation factor VIIa derivative, FacVII and FacVIIa conjugates each prepared by linking a polymer capable of extending the blood half-life to the derivative, FacVII and VIIa complexes each prepared by linking a carrier to the conjugate, genes encoding the FacVII and FacVIIa derivatives, expression vectors comprising the genes, transformants introduced with the expression vectors, a method for preparing the FacVII and FacVIIa derivatives using the transformants, a method for preparing the FacVIIa conjugate and complex, a FacVIIa complex prepared by the method, a pharmaceutical composition for the prevention or treatment of hemophilia comprising the derivative, conjugate, or complex as an active ingredient, and a pharmaceutical composition for blood coagulation comprising the derivative, conjugate, or complex as an active ingredient. Further, the present invention relates to a method for preventing or treating hemophilia or for promoting blood coagulation, comprising administering to a subject a therapeutically effective amount of the composition. The FacVII or FacVIIa derivative of the present invention is able to bind with a carrier capable of improving the blood half-life while maintaining the activity of FacVII or FacVIIa, and they can be widely used in the development of effective prophylactic or therapeutic agent for hemophilia.La presente invención se refiere a un derivado del factor de coagulación sanguínea VII, un derivado del factor de coagulación sanguínea Vila, conjugados de FacVll y FacVlla preparados cada uno enlazando un polímero que puede extender la semivida en sangre al derivado, complejos de FacVll y Vila preparados cada uno enlazando un vehículo al conjugado, genes que codifican los derivados de FacVll y FacVIIa, vectores de expresión que comprenden los genes, transformantes introducidos con los vectores de expresión, un procedimiento para preparar los derivados
