SRINIVAS, Mangala,KOSHKINA, Olga,FIGDOR, Carl Gustav,DE VRIES, Ingrid Jolanda Monique
申请号：
EPEP2017/055827
公开号：
WO2017/153605A1
申请日:
2017.03.13
申请国别(地区):
WO
年份:
2017
代理人:
摘要：
The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohoi and optionally a metal compound, comprising the steps of: a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant comprising polyvinylalcohoi under sonication to obtain a second liquid mixture, c) maintaining the sonication of the second liquid mixture while cooling, d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, e) separating the beads from the suspension and preparing a water suspension of the beads and f) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. The invention further relates to beads having close F-H20 interactions, which are suitable for imaging purposes.Linvention concerne un procédé de préparation de billes comprenant un polymère hydrophobe biocompatible, un perfluorocarbone, un alcool polyvinylique et éventuellement un composé métallique, comprenant les étapes consistant : a) à ajouter le perfluorocarbone et éventuellement le composé métallique à une solution du polymère hydrophobe biocompatible dans un solvant polaire de manière à fournir un premier mélange liquide, b) à ajouter le premi
