TARIQ GHAYUR,CELIA PATRICIA SHORROCK,JULIA ELIZABETH THOMPSON,SIMON NICHOLAS LENNARD,RICHARD W. DIXON,MIKE ROGUSKA,MICHAEL WHITE,BORIS LABKOVSKY,JOCHEN SALFELD,ALEXANDER ROBERT DUNCAN,SIMON MARK BROCK
申请号：
MYPI 20010574
公开号：
MY146017A
申请日:
2001.02.09
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
ANTIBODIES THAT BIND HUMAN INTERLEUKIN-18 (HIL-18) ARE PROVIDED, IN PARTICULAR ANTIBODIES THAT BIND EPITOPE(S) OF HUMAN IL-18. THE ANTIBODIES CAN BE , FOR EXAMPLE, ENTIRELY HUMAN ANTIBODIES, RECOMBINANT ANTIBODIES, OR MONOCLONAL ANTIBODIES. PREFERRED ANTIBODIES HAVE HIGH AFFINITY FOR HIL-18 AND NEUTRALIZE HIL-18 ACTIVITY IN VITRO AND IN VIVO. AN ANTIBODY OF THE INVENTION CAN BE A FULL-LENGTH ANTIBODY OR AN ANTIGEN-BINDING PORTION THEREOF. METHOD OF MAKING AND METHOD OF USING THE ANTIBODIES OF THE INVENTION ARE ALSO PROVIDED. THE ANTIBODIES, OR ANTIBODY PORTIONS, OF THE INVENTION ARE USEFUL FOR DETECTING HIL-18 AND FOR INHIBITING HIL-18 ACTIVITY, E.G., IN A HUMAN SUBJECT SUFFERING FROM A DISORDER IN WHICH HIL-18 ACTIVITY IS DETRIMENTAL.
