Duncan, Alexander Robert,Labkovsky, Boris,Shorrock, Celia Elizabeth,Salfeld, Jochen,Mankovich, John,Thompson Julia Elizabeth,White, Michael,Roguska, Mike,Dixon, Richard W.,Brocklehurst, Simon Mark,Len
申请号：
AU2011201536
公开号：
AU2011201536B2
申请日:
2011.04.05
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2011201536B220130704.pdf#####ANTIBODIES THAT BIND HUMAN INTERLEUKIN-18 AND METHODS OF MAKING AND USING Abstract Antibodies that bind human interleukin-18 are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which HIL-1 8 activity is detrimental.
