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ANTIBODIES THAT BIND HUMAN INTERLEUKIN-18 AND METHODS OF MAKING AND USING
专利权人:
发明人:
申请号:
HK11112995.7
公开号:
HK1158663A
申请日:
2003.04.28
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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