Hinds, Kenneth,Lewis, Danny,Schmidt, Paul,Campbell, Kathleen M.
申请号：
AU2010212312
公开号：
AU2010212312B2
申请日:
2010.08.12
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010212312B220120517.pdf#####ABSTRACT The invention is directed to a single-step method for rapidly and efficiently 5 preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such 10 as insulin, with poly(ethylene glycol) at residue PheBl. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.
