DERIVES HETEROCYCLIQUES BICYCLIQUES SUBSTITUES UTILES EN TANT QU'INHIBITEURS DE CANAL ROMK

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

GUNAGA, PRASHANTHA,BHIDE, RAJEEV S.,BORA, RAJESH ONKARDAS,PANDA, MANORANJAN,YADAV, NAVNATH DNYANOBA,PRIESTLEY, ELDON SCOTT,RICHTER, JEREMY

申请号：

CA3042380

公开号：

CA3042380A1

申请日:

2017.11.02

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III)； each W is independently NR1b or O； Z is a bond or CHR1d； and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

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http://www.ckcest.cn/home/