Ronald T. Raines,George N. Phillips, Jr.,R. Jeremy Johnson,Jason G. McCoy
申请号：
US14046671
公开号：
US09234191B2
申请日:
2013.10.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing and using the RNase 1 variants.
