Ronald T. Raines,George N. Philllips, JR.,R. Jeremy Johnson,Jason G. McCoy
申请号：
US13243373
公开号：
US20120009173A1
申请日:
2011.09.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
