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METHODS FOR PRODUCING MACROLIDES AND KETOLIDES, AND INTERMEDIATE COMPOUNDS FOR THEIR PRODUCTION
专利权人:
ИНК. (US);СЕМПРА ФАРМАСЬЮТИКАЛЗ
发明人:
ПЕРЕЙРА Дэвид Е. (US)
申请号:
RU2012150753/04
公开号:
RU2012150753A
申请日:
2011.05.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of obtaining a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is hydrogen, an acyl or a fragment of a prodrug; X is H; a Y represents OR; where R is a monosaccharide, disaccharide, alkyl, arylalkyl or heteroarylalkyl, each of which is optionally substituted, or acyl or C (O) NRR, where each R and R are independently selected from the group consisting of hydrogen, hydroxy, alkyl, heteroalkyl, alkoxy, aryl, arylalkyl, heteroaryl and heteroarylalkyl, each of which is optionally substituted, and dimethylaminoalkyl, acyl, sulfonyl, ureido and carbamoyl; or R and R, together with a nitrogen atom attached to them, form a possibly substituted heterocycle; or X and Y together with a carbon atom attached thereto form a carbonyl; V represents C (O), C (= NR), CH (NR, R) or N (R) CH; where N (R) is attached to the C-10 carbon atom; where R is hydroxy or alkoxy; each R and R is independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, heteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl, each of which is optionally substituted, and dimethylaminoalkyl, acyl, sulfonyl, ureido and carbamoyl; R represents hydrogen, hydroxy, alkyl, alkoxy, heteroalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, each of which is optionally substituted, or dimethylaminoalkyl, acyl, sulfonyl, ureido or carbamoyl; W represents H, F, Cl, Br, I or OH; A represents CH, C (O), C (O) O, C (O) NH, S (O), S (O) NH or C (O) NHS (O); B represents (CH) where n is an integer from 0 to 10; or an unsaturated carbon chain containing from 2 to 10 carbon atoms; and C represents hydrogen, hydroxy, alkyl, alkoxy, get�1. Способ получения соединения формулы (I)или его фармацевтически приемлемой соли, где:Rпредставляет собой водород, ацил или фрагмент пролекарства;X представляет собой Н; a Y представляет собой OR; где Rпредставляет собой моносахарид, дисахарид, алкил, арилалкил или гетероарилалкил, каждый из которых возможно замещен, или
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