Disclosed herein are antibodies directed against CRTAM, nucleic acids encoding such antibodies, host cells comprising such nucleic acids encoding the antibody, methods for preparing anti-CRTAM antibodies, and methods for the treatment of diseases, e.g., human cancers, including but not limited to small cell lung cancer, non-small cell lung cancer (including squamous carcinomas and adenocarcinomas) skin cancer including melanoma, breast cancer (including TNBC), colorectal cancer, gastric cancer, ovarian cancer, cervical cancer, prostate cancer, kidney cancer, liver cancer including hepatocellular carcinoma, pancreatic cancer, head and neck cancer, nasopharyngeal cancer, oesophageal cancer, bladder cancer and other uroepithelial cancers, stomach cancer, glioma, glioblastoma, testicular, thyroid, bone, gallbladder and bile ducts, uterine, adrenal cancers, sarcomas, GIST, neuroendocrine tumours, and haematological malignancies.L'invention concerne des anticorps dirigés contre CRTAM, des acides nucléiques codant pour ces anticorps, des cellules hôtes comprenant ces acides nucléiques codant pour l'anticorps, des procédés de préparation d'anticorps anti-CRTAM, et des procédés de traitement de maladies, par exemple, de cancers humains, comprenant, de manière non restrictive, le cancer du poumon à petites cellules, le cancer du poumon non à petites cellules (y compris les carcinomes squameux et adénocarcinomes), le cancer de la peau y compris le mélanome, le cancer du sein (y compris le TNBC) le cancer colorectal, le cancer gastrique, le cancer de l'ovaire, le cancer du col de l'utérus, le cancer de la prostate, le cancer du rein, le cancer du foie, y compris le carcinome hépatocellulaire, le cancer du pancréas, le cancer de la tête et du cou, le cancer du rhinopharynx, le cancer de l'oesophage, le cancer de la vessie et d'autres cancers uroépithéliaux, le cancer de l'estomac, le gliome, Le glioblastome, les cancers des testicules, de la thyroïde, des os, de la vésicule bili
