The Regents of the University of Colorado, a body corporate;Colorado State University Research Foundation
发明人:
Steven Dow,Michael R. Lappin,William H. Wheat,Lyndah Chow,Daniel P. Regan,Thomas J. Anchordoquy
申请号：
US15476723
公开号：
US10512687B2
申请日:
2017.03.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes； a mixture of toll like receptor 3 (TLR3) and toll like receptor 9 (TLR9) ligands； and a cellular adhesion agent, and methods of using such compositions. In certain aspects, disclosed compositions are administered to a mammal to induce a non-specific innate immune response at mucosal surfaces. In further aspects, disclosed compositions are administered to a mammal in conjunction with an antigen to enhance the immune response of the mammal to the antigen.
