Colorado State University Research Foundation;The Regents of The University of Colorado
发明人:
Wheat, William,Chow, Lyndah,Regan, Daniel,Anchordoquy, Thomas,Dow, Steven,Lappin, Michael
申请号:
AU2017240761
公开号:
AU2017240761A1
申请日:
2017.03.31
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes; a mixture of toll like receptor 3 (TLR3) and toll like receptor 9 (TLR9) ligands; and a cellular adhesion agent, and methods of using such compositions. In certain aspects, disclosed compositions are administered to a mammal to induce a non-specific innate immune response at mucosal surfaces. In further aspects, disclosed compositions are administered to a mammal in conjunction with an antigen to enhance the immune response of the mammal to the antigen.