COLORADO STATE UNIVERSITY RESEARCH FOUNDATION;THE REGENTS OF THE UNIVERSITY OF COLORADO
发明人:
DOW, STEVEN,LAPPIN, MICHAEL,WHEAT, WILLIAM,CHOW, LYNDAH,REGAN, DANIEL,ANCHORDOQUY, THOMAS
申请号：
CA3019515
公开号：
CA3019515A1
申请日:
2017.03.31
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes； a mixture of toll like receptor 3 (TLR3) and toll like receptor 9 (TLR9) ligands； and a cellular adhesion agent, and methods of using such compositions. In certain aspects, disclosed compositions are administered to a mammal to induce a non-specific innate immune response at mucosal surfaces. In further aspects, disclosed compositions are administered to a mammal in conjunction with an antigen to enhance the immune response of the mammal to the antigen.
