THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE CHILDREN'S HOSPITAL OF PHILADELPHIA;THE CHILDRENS HOSPITAL OF PHILADELPHIA
发明人:
MILONE, MICHAEL C.,ARRUDA, VALDER,RICHMAN, SARAH,SAMELSON-JONES, BENJAMIN
申请号：
CA3020599
公开号：
CA3020599A1
申请日:
2017.04.14
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention includes compositions comprising at least one chimeric alloantigen receptor (CALLAR) specific for an alloantibody, vectors comprising the same, compositions comprising CALLAR vectors packaged in viral particles, and recombinant T cells comprising the CALLAR. The invention also includes methods of making a genetically modified T cell expressing a CALLAR, wherein the expressed CALLAR comprises a Factor VIII or fragment thereof extracellular domain.
