The Trustees of the University of Pennsylvania;The Children's Hospital of Philadelphia
发明人:
MILONE, Michael, C.,ARRUDA, Valder,RICHMAN, Sarah,SAMELSON-JONES, Benjamin
申请号：
EP17783306
公开号：
EP3443076A4
申请日:
2017.04.14
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention includes compositions comprising at least one chimeric alloantigen receptor (CALLAR) specific for an alloantibody, vectors comprising the same, compositions comprising CALLAR vectors packaged in viral particles, and recombinant T cells comprising the CALLAR. The invention also includes methods of making a genetically modified T cell expressing a CALLAR, wherein the expressed CALLAR comprises a Factor VIII or fragment thereof extracellular domain.
