The Trustees of the University of Pennsylvania;The Children's Hospital of Philadelphia
发明人:
Milone, Michael C.,Arruda, Valder,Richman, Sarah,Samelson-Jones, Benjamin
申请号：
AU2017248817
公开号：
AU2017248817A1
申请日:
2017.04.14
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The invention includes compositions comprising at least one chimeric alloantigen receptor (CALLAR) specific for an alloantibody, vectors comprising the same, compositions comprising CALLAR vectors packaged in viral particles, and recombinant T cells comprising the CALLAR. The invention also includes methods of making a genetically modified T cell expressing a CALLAR, wherein the expressed CALLAR comprises a Factor VIII or fragment thereof extracellular domain.
