PROCEDES ET PRODUITS PERMETTANT DE MODULER LA COMPOSITION DU MICROBIOTE AFIN D'AMELIORER L'EFFICACITE D'UN TRAITEMENT ANTICANCEREUX IMPLIQUANT UN INHIBITEUR DES POINTS DE CONTROLE DU SYSTEME IMMUNITAIRE
INSTITUT GUSTAVE ROUSSY;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PARIS-SUD;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
The present invention relates to the role of the microbiota in the efficacy of cancer treatments with a drug blocking an. immune checkpoint and provides methods and probiotics to improve the efficacy of such a treatment in patients in need thereof. More particularly, the invention pertains to the use of vancomycin or penicillin to modulate the gut microbiota to potentiate the anticancer effects of anti-CTLA4 molecules. B. fragilis or fecal microbial transplantation of a defined composition enriched in immunogenic Bacteroides spp. can also be used as a probiotic to that aim.
