Products for modulating microbiota composition for improving the efficacy of a cancer treatment with an immune checkpoint blocker

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专利权人:

发明人:

申请号：

EP14190167.8

公开号：

EP3012270A1

申请日:

2014.10.23

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to the role of the microbiota in the efficacy of cancer treatments with a drug blocking an immune checkpoint, and provides methods and probiotics to improve the efficacy of such a treatment in patients in need thereof. More particularly, the invention pertains to the use of vancomycin or penicillin to modulate the gut microbiota to potentiate the anticancer effects of anti-CTLA4 molecules. B. fragilis can also be used as a probiotic to that aim.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/