METHODS AND PRODUCTS FOR MODULATING MICROBIOTA COMPOSITION FOR IMPROVING THE EFFICACY OF A CANCER TREATMENT WITH AN IMMUNE CHECKPOINT BLOCKER

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专利权人:

发明人:

申请号：

EP15794643.5

公开号：

EP3209692A2

申请日:

2015.10.23

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention relates to the role of the microbiota in the efficacy of cancer treatments with a drug blocking an. immune checkpoint and provides methods and probiotics to improve the efficacy of such a treatment in patients in need thereof. More particularly, the invention pertains to the use of vancomycin or penicillin to modulate the gut microbiota to potentiate the anticancer effects of anti-CTLA4 molecules. B. fragilis or fecal microbial transplantation of a defined composition enriched in immunogenic Bacteroides spp. can also be used as a probiotic to that aim.

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中国工程科技知识中心

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http://www.ckcest.cn/home/