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METHODS AND PRODUCTS FOR MODULATING MICROBIOTA COMPOSITION FOR IMPROVING THE EFFICACY OF A CANCER TREATMENT WITH AN IMMUNE CHECKPOINT BLOCKER
专利权人:
发明人:
申请号:
EP15794643.5
公开号:
EP3209692A2
申请日:
2015.10.23
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to the role of the microbiota in the efficacy of cancer treatments with a drug blocking an. immune checkpoint and provides methods and probiotics to improve the efficacy of such a treatment in patients in need thereof. More particularly, the invention pertains to the use of vancomycin or penicillin to modulate the gut microbiota to potentiate the anticancer effects of anti-CTLA4 molecules. B. fragilis or fecal microbial transplantation of a defined composition enriched in immunogenic Bacteroides spp. can also be used as a probiotic to that aim.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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