A method for sterilizing an article in a sealable sterilization chamber (10), said method comprising the steps of a. place the item in the sterilization chamber (10), b. seal the chamber (10), c. apply a vacuum of a first pressure to the chamber (10), the first pressure being sufficient to evaporate an aqueous solution of hydrogen peroxide to form water vapor and hydrogen peroxide gas at the temperature of an atmosphere in the chamber (10) d. interrupt any removal of any component of the chamber's atmosphere after applying the vacuum at least until the end of a second exposure period, e. during a first exposure period, humidify the chamber atmosphere only by injecting aqueous hydrogen peroxide solution evaporated into the sealed chamber (10), and terminate the injection once a second preselected pressure, greater than the first pressure, is reached in the sealed sterilization chamber (10), in which the injection of evaporated hydrogen peroxide solution includes injecting repeated pulses of evaporated hydrogen peroxide solution at a pulse volume of less than 75 μl； F. during the second exposure period following the first exposure period, inject a gas containing dry ozone or nitric oxide into the chamber (10), thereby humidifying the chamber's atmosphere improves the sterilization efficiency of the gas that Contains dry ozone or nitric oxide to achieve sterilization of the item； g. remove the residual sterilizer from the chamber (10) at the end of the second exposure period, and h. remove the sterilized article from the chamber (10).Un método para esterilizar un artículo en una cámara de esterilización sellable (10), comprendiendo dicho método las etapas de a. colocar el artículo en la cámara de esterilización (10), b. sellar la cámara (10), c. aplicar a la cámara (10) un vacío de una primera presión, siendo la primera presión suficiente para evaporar una solución acuosa de peróxido de hidrógeno para formar vapor de agua y peróxido de hidrógeno gaseoso a la temperatur
