An intraosseous access system may include a hub coupled to a cannula for introduction into a bone of a patient, and a securement device that can couple with the hub when transitioned from an open orientation to a closed orientation. The securement device may include a first segment and a second segment spaced apart in a securement device open orientation, and approximated and secured to each other in a securement device closed orientation. The first segment may include a first receptacle that receives a portion of the hub therein and contacts the hub to restrain movement of the hub relative to the securement device when the securement device is coupled with the hub in the closed orientation. The first segment also may include a first arm biasing the first receptacle toward the hub when the securement device is coupled with the hub in the closed orientation.
