Hose connection system for narially sensitive diagnostic devices. At least some of the illustrative embodiments are systems including a test device and a nasal cannula. The test device includes a first port configured to sense an attribute of airflow, and a second port configured to sense an attribute of airflow. The nasal cannula includes a first hose configured to fluidly couple on a device-end to the first port (and the first hose configured to fluidly couple between the first port and a first naris of a patient), and a second hose configured to fluidly couple on a device-end to the second port (and the second hose configured to fluidly couple between the second port and a second naris of the patient). The nasal cannula is configured such that the first hose only couples to the first port and the second hose only couples to the second port.