The invention is generally directed to systems and methods for fluid control,and more particularly to systems and methods for power and flow rate control foraspiration. In accordance with one embodiment, an aspiration system includesan aspiration line having distal and proximal ends and an aspiration port definedin the distal end； a fluid transport device operatively coupled to the proximalend of the aspiration line； and a flow restrictor operatively coupled to the aspirationline in between the fluid transport device and the aspiration port. To measureocclusion within the line, first and second pressure sensors are utilized, thefirst sensor being operatively coupled to the aspiration line between the portand the restrictor and the second sensor being operatively coupled to the aspirationline between the restrictor and the fluid transport device. The pressure differentialbetween the two sensors can provide an indication of the onset, presence, and/orelimination of an occlusion.
