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КОМБИНИРОВАННАЯ ТЕРАПИЯ ДЛЯ ЛЕЧЕНИЯ РАКА И ДИАГНОСТИЧЕСКИЕ АНАЛИЗЫ, ИСПОЛЬЗУЕМЫЕ В КОМБИНИРОВАННОЙ ТЕРАПИИ
专利权人:
ЭББОТТ ЛЭБОРЕТРИЗ (US)
发明人:
ШАХ Омар Джамиль (US),ШЭНЬ Юй (US),ЛИНЬ Сяоя (US),АНДЕРСОН Марк (US),ХУАН Сяоли (US),ЛИ Цзюньлин (US),ЛИ Лэймин (US)
申请号:
RU2012127812/15
公开号:
RU2012127812A
申请日:
2010.12.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a patient suffering from cancer, which includes the steps of:a) administering to a patient suffering from cancer, a therapeutically effective amount of at least one agent inducing polyploidy andb) administering to the patient a therapeutically effective amount of at least one inhibitor of the protein Bcl-2 family.2. The method of claim 1, wherein at least one agent inducing polyploidy is a kinase inhibitor Aurora.3. The method of claim 2, wherein the kinase inhibitor is an inhibitor of Aurora kinase Aurora B.4. The method of claim 3, wherein the Aurora B kinase inhibitor is VX-680, AZD1152, ZM44739 or gersperadinom.5. The method of claim 1, wherein the inhibitor of protein Bcl-2 family is ABT-263, ABT-737, selective inhibitors of Bcl-XL or combinations thereof.6. The combination of therapeutic agents for the treatment of a patient suffering from cancer, which includes:a) at least one agent inducing polyploidy used for induction of polyploidization in one or more cancer cells of the patient andb) at least one inhibitor of the protein Bcl-2 family.7. A combination according to claim 6, wherein at least one agent inducing polyploidy is a kinase inhibitor Aurora.8. A combination according to claim 7, wherein the kinase inhibitor is an Aurora kinase inhibitor of Aurora B.9. A combination according to claim 8, wherein the Aurora B kinase inhibitor is VX-680, AZD1152, ZM44739 or gersperadinom.10. The combination of claim 6, wherein the inhibitor of the protein Bcl-2 family is ABT-263, ABT-737, selective inhibitors of Bcl-XL or combinations thereof.11. A method of classifying a patient to be treated means inducing polyploidy, an inhibitor of Bcl-2 protein family or combination of agents inducing polyploidy, and Bcl-2 family protein inhibitor which comprises the steps of:a) obtaining a test sample from a patientb) determining in the sample the presence or absence of at least one mutation in at least one gene selected from the group consisting of: a ge
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