PROBLEM TO BE SOLVED: To obtain a pharmaceutical to suppress gene expression of matrix metalloproteinase-1, thereby suppressing skin wrinkles, preventing reduction of elasticity, preventing skin sagging, furthermore, the pharmaceutical being effective against skin damages from wound, burn, ulceration, sunlight, and against vesicular, lichenous, granulomatous, or other various skin disorders, and, in addition to the effectiveness to the skin, the pharmaceutical being effective for the prevention and treatment of arthritis and joint pain.SOLUTION: The inventors have found out that the problem can be solved by mixing an extract of mulberry branch as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】 本発明の目的は、マトリックスメタロプロテアーゼ-1遺伝子発現を抑制し、皮膚のシワを抑制し、弾力性の低下を防ぎ皮膚のタルミを防ぎ、さらに、創傷、火傷、潰瘍性、日光による皮膚損傷、水疱性、苔癬性、肉芽性等の各種皮膚疾患にも有効であり、皮膚以外にも、関節炎、関節痛の予防や治療にも有効である製剤を得ることにある。【解決手段】 桑枝の抽出物を有効成分として配合すると、上記の目的を達することがわかった。【選択図】なし
