HANK MICHAEL JAMES PETRASSI,JON LOREN,BAO NGUYEN,VINCE YEH,XIAODONG LIU,VALENTINA MOLTENI,JULIET NABAKKA,XIAOLIN LI
申请号：
ARP120103223
公开号：
AR087753A1
申请日:
2012.08.31
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
They contribute to the inhibition of quinase proteins and to the use of these compounds to treat, alleviate or prevent disorders associated with abnormal or unregulated activity of quinase. In some of the outcomes, this document provides methods for the use of these compounds to treat, mitigate or prevent diseases or disorders associated with abnormally activated c-kit or c-kit and PDGF (PDGFRA, pdgrb). Claim 1: a compound of formula (1) or formula (2),e. Or select an acceptable salt from h, halo, c83218331 asphalt, wherein: m is 1, r83044；C₁₋₆ haloalkyl,C₁₋₆ haloalkoxy,deuterio alquilo C deuterado -CN - (CR) OR-C (O) R- (CR) C (3DO) ORR830404,- (CR) R- ((CR) O) R- (CR) O (CR) R- (CR) C (3DO) R-C (3DO) N (R)-Or83088,and - (CR⁹₂) ₙCN； or m is 4 and R²⁰ is deuterium； R¹ is selected from C₁₋₆ alkyl and halo； each R¹¹ is independently selected from H, halo and C₁₋₆ alkyl；L1 is a link, - nh-o-c (o) NH -；L es - (CR) --CHR⁶-,-(cr8313； 8322) - i.e. 8345；- en...- (CR) C (3DO) --C (= O) or (CR) 8313； - 832245； -,- (CR) OC (3DO) NR --(cr.8313；) - No. 834508； (= O) (cr.83313；) No. 8322245； -,-(cr8313； 8322) - No. 834508； C (= O) -,O - (cr8313； 8322) - 834508； (= O) O； R2 is cubic or cubic centimeter；R³ is selected from an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, a piperidinone, an oxazolidin-2-one, pyrrolidinone, a pyrrolidin-2-one and a 4-6 membered substituted heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, wherein the 4-6 membered substituted heterocycloalkyl is substituted with 1-4 substituents independently selected from C₁ alkyl ₋₆,halo, -CN, C₁₋₆ haloalkyl,-Or83088,-C (3DO) OR-C (3DO) R-C (3DO) R-C (3DO) OR- (CR) OR-O (CR) OR-C (3DO) O (CR) OR-N (R)-C (3DO) NR-8308； C (= O) or8308；-8308jc (= O) (cr8313)； 832222). - 834508 or83088；-83088 (cr8313)； - 8345 (or83088)；- 8308th；]-N (C (3DO) OR)R8322,- (CR) Ralcoxilo C deuterado -S (3DO) R-S (3DO) R-S (3DO) R-S (3DO) N (R)-S (3DO) NHC
