Cals, Joseph Maria Gerardus Barbara,Nabuurs, Sander Bernardus
申请号：
UAA201607189
公开号：
UA117941C2
申请日:
2014.12.03
申请国别(地区):
UA
年份:
2018
代理人:
摘要：
The present invention relates to compounds according to Formula I: Wherein: A11-A14 are N or CR11, CR12, CR13, CR14, respectively, with the proviso that no more than two of the four positions A can be simultaneously N； R1 is C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, (di)C(1-6)alkylamino, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(l-3)alkyl)amino, with all carbon atoms of alkyl groups optionally substituted with one or more F and all carbon atoms of cycloalkyl groups optionally substituted with one or more F or methyl； R2 and R3 are independently H, F, methyl, ethyl, hydroxy, methoxy or R2 and R3 together is carbonyl, all alkyl groups, if present, optionally being substituted with one or more F； R4 is Η or C(l-6)alkyl； R5 is H, hydroxyethyl, methoxyethyl, C(l-6)alkyl, C(6-10)aryl, C(6-10)arylC(l-3)alkyl, C(l-9)heteroaryl, C(l-9)heteroarylC(l-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(l-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(l-3)alkyl, all groups optionally substituted with one or more F, CI, C(l-2)alkyl, C(l-2)alkoxy or cyano； the sulfonyl group with R1 is represented by one of R7, R8 or R9； the remaining R6-RH are independently H, halogen, C(l-3)alkoxy, (di)C(l-3)alkylamino or C(l-6)alkyl, all of the alkyl groups optionally being substituted with one or more F； and Ri5 and Ri6 are independently H, C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(l-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(l-3)alkyl, C(2-5)het-erocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with one or more F, CI, C(1-2)alkyl, C(1-2)alkoxy or cyano. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases.Даний винахід стосується сполук формули І Мета або параФормула І,де А11-А14 являють собою N або CR11, CR12, CR13, CR14, відповідно, за умови, що не більше ніж в двох положеннях з чотирьох А можуть одночасно являти собою N； R1
