Humane monoklonale anti-TNF alpha Antikörper

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专利权人:

Bayer HealthCare LLC

发明人:

Petra Boyle,Gayle D. Wetzel,Kenneth J. Lembach

申请号：

DE69427928

公开号：

DE69427928T3

申请日:

1994.02.21

申请国别(地区):

DE

年份:

2012

代理人:

摘要：

Human monoclonal antibodies (mAbs) which bind to human TNFα. Autoantibodies of both the IgM and IgG isotypes are disclosed. A preferred human monoclonal antibody is known as B5 (F78-1A10-B5 mAb) and it binds to recombinant human TNFα (rhTNFα) in ELISA format with a titer comparable to three high affinity neutralizing mouse mAbs. It also binds to cell surface TNFα and prevents TNFα secretion by human monocyte cell lines.

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