FULLY HUMAN ANTIBODY TO HUMAN TNFA. MOLECULAR EVOLUTION AND USE THERE OF.

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专利权人:

发明人:

LIU QINGFA

申请号：

IN1951/MUMNP/2011

公开号：

IN279802B

申请日:

2011.09.19

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

A HUMAN ANTI-TUMOR NECROSIS FACTOR ALPHA MONOCLONAL ANTIBODY AND USE THEREOF A protein capable of specifically binding to human TNFa (tumor necrosis factor alpha) is provided, i.e. human anti-TNFa monoclonal antibody derived from human B cells. The light and heavy chains of the antibody comprise the amino acid sequences as shown in SEQ ID NO: 8 and SEQ ID NO: 9 or 10, respectively. The encoding gene, the Fab antibody and the use in the preparation of the medicament for treating TNFa-related inflammation of the anti-TNFa antibody are also provided.

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