An infusion set (10, 200) preferably for use with an inserter is disclosed. The infusion set (10, 200) includes a septum cap (70, 210) that encapsulates an upper resilient septum (80) and a lower resilient septum (90) of a base (40), and includes at least one radial port (130, 230) to receive insertion of a blunt cannula (110) when an extension set hub (30, 180) is engaged with the infusion set (10, 200) in a direction substantially parallel to the skin surface. The extension set hub (30, 180) is configured to provide a snap-fit engagement with the septum cap (70, 210), wherein the blunt cannula (110) of the extension set hub (30, 180) is guided through the radial port (130, 230) of the septum cap (70, 210) and penetrates the interface between the upper septum (80) and the lower septum (90). The extension set hub (30, 180) and the septum cap (70, 210) can be rotated in a 360 degree manner about the base (40) of the infusion set.
