The present invention relates to: a monoclonal antibody which can bind to an extracellular domain of human CC chemokine receptor 1 (CCR1) and can inhibit the activation of CCR1 with human CC chemokine ligand 15 (CCL15), or an antibody fragment of the monoclonal antibody； a hybridoma which can produce the antibody； a nucleic acid which has a nucleotide sequence encoding the antibody or the antibody fragment； a transformed cell which contains a vector carrying the nucleic acid； a method for producing the antibody or the antibody fragment using the hybridoma or the transformed cell； a therapeutic agent and a diagnostic agent, each of which contains the antibody or the antibody fragment； and a method for treating a CCR1-related disease and a method for diagnosing a CCR1-related disease, in each of which the antibody or the antibody fragment is used.本發明係關於一種結合於人類CC趨化素受體1(CCR1)之細胞外區域而抑制由人類CC趨化素配體15(CCL15)引起之CCR1之活化的單株抗體或該抗體片段、產生該抗體之融合瘤、具有編碼該抗體或該抗體片段之鹼基序列的核酸、含有包含該核酸之載體之轉形細胞、使用該融合瘤或該轉形細胞之該抗體或該抗體片段之製造方法、包含該抗體或該抗體片段之治療藥及診斷藥、以及使用該抗體或該抗體片段之CCR1相關疾病之治療方法及診斷方法。
